We are pleased to host the 27th annual meeting on genome science, The Biology of Genomes, which will begin at 7:30 pm on Tuesday, May 6, 2014 and run through lunch on Saturday, May 10. The 2014 meeting will address DNA sequence variation and its role in molecular evolution, population genetics and complex diseases, comparative genomics, large-scale studies of gene and protein expression, and genomic approaches to ecological systems. Both technologies and applications will be emphasized. In addition there will be a special session on the ethical, legal and social implications of genome research.