We are pleased to host the third meeting on Personal Genomes: Discovery, Treatment & Outcomes which combines previous CSHL meetings on personal genomes and on pharmacogenomics. The meeting will begin on Wednesday November 12 at 7.30pm and conclude with lunch on Saturday November 15. As genome sequencing becomes routine, the availability of individualized genetic/genomic information is changing and challenging the practice of medicine. Stratification of common diseases based on the individual's genetics is increasingly possible, as is the best choice of pharmacological agent to be deployed to combat that disease. At the same time, personal genome sequencing generates large amounts of data that will need to be integrated into medical decision making. This conference will explore the current state of individual genomics at the level of the underlying genome biology and its application in pharmacology and medicine. The conference will also showcase other areas (eg. ancestry) where the ready availability of personal genetic information represents a powerful new resource for analysis and understanding.