In 2008, the Large Hadron Collider will begin taking data and start its exploration of new physics beyond the Standard model at the TeV scale. The Gamma-Ray telescope GLAST will also be launched in 2008. Meanwhile the ground-based telescopes as HESS, MAGIC, VERITAS, MILAGRO and ARGO have observed Gamma-Rays at the TeV scale or higher with unprecented accuracy for years. Neutrino experiments like Antares and IceCube will soon start to run at similar and higher energies.