Paradigms, Methodology and Software Architectures for Large Scale Distributed and Real-Time Simulations; Paradigms, Modelling, Architecture and Environments for Large Scale Real-time Systems and Concurrent Systems with Hard and Soft Real-Time Constraints; Simulation Studies at Large and Very Large Scale; Languages and Tools, Development Environments, Data Interfaces, Network Protocols and Model Repositories that address Very Large Simulations; Data Management and Distribution Issues, Interest Management, Semantic Modeling, Multi-resolution Modeling, Dead-Reckoning Mechanisms; Pervasive and Ubiquitous Computing Architectures and Applications that involve Simulations and/or adhere to Real-Time Constraints; Simulation based Virtual Environments and Mixed Reality Systems, Serious Gaming and Massive Multiplayer Online Games (MMOG) applications, architectures and scalability issues; Design Issues, Interaction Designs, Human Commuter Interaction Issues raised by Large Scale DS-RT Systems.