VLSI-SoC 2013 is the 21st in a series of international conferences sponsored by IFIP TC 10 Working Group 10.5, IEEE CEDA, and IEEE CASS, which explores the state-of-the-art in the areas that surround Very Large Scale Integration (VLSI) and System-on-Chip (SoC). Previous conferences have taken place in Edinburgh, Trondheim, Tokyo, Vancouver, Munich, Grenoble, Gramado, Lisbon, Montpellier, Darmstadt, Perth, Nice, Atlanta, Rhodes, Florianópolis, Madrid, Hong Kong, and Santa Cruz. The purpose of VLSI-SoC is to provide a forum to exchange ideas and showcase research as well industrial results in EDA, design methodology, test, design, verification, devices, process, system issues, and application domains of VLSI and SoC.