KSE 2018 solicits contributions dealing with any aspects of Knowledge and Systems Engineering. The organizers of the conference invite the papers on the following themes, but not limited to: • Natural Language Processing • Multimedia & Pattern Recognition • Evolutionary Learning • Information Security • Biomedical Information Processing • Knowledge Representation and Reasoning • Data Mining & Big Data • Information System Engineering • Knowledge Management • System Engineering • Software Systems Engineering • Web Services • Cloud Computing, Computing Models • Human Machine Interaction • Fuzzy Logic and Application