The second International Conference on High Performance Computing and Applications (HPCA2009) will be held in Shanghai, a beautiful, dynamic, and modern city in China, August 10--12, 2009. It will serve as a forum to present current work by researchers and software developers from around the world as well as to highlight activities in the high performance computing area. The conference will emphasize both design and analysis of high performance computing algorithms, tools, platforms, and their scientific, engineering, medical and industrial applications. The conference will be organized by The Shanghai University. It aims to bring together research scientists, application pioneers, and software developers to discuss problems and solutions and to identify new issues in this area. Proceedings of presented and refereed papers will be published with Springer as a volume of LNCS which are SCI-indexed(http://www.springer.com/lncs). And selected papers will be asked to be revised and extended for publication in Springer's Computing (http://www.springer.com/springerwiennewyork/mathematics/journal/607) and International Journal of Numerical Analysis and Modeling (http://www. math.ualberta.ca/ijnam).