The 7th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics (ACM BCB) is the flagship conference of the ACM SIGBio. ACM-BCB 2016 is the conference's seventh year, building upon the success of the first six meetings in Niagara Falls, Chicago, Orlando, Washington DC, Newport Beach, and Atlanta. ACM-BCB 2016 will be held in Seattle, WA, October 2-5, 2016. The conference is the premier dissemination forum for interdisciplinary research linking computer science, mathematics, statistics, biology, bioinformatics, biomedical informatics, and health informatics. The past few decades have seen tremendous growth in the scale and complexity of biological and medical data including recent mainstream recognition of big data challenges. This conference serves to showcase leading-edge research on new technologies and techniques around gathering, processing, analyzing, and modeling of data and information for a variety of scientific, clinical, and healthcare applications, from bench to bedside.