This special annual celebration (“Double Helix Day”) is intended to coincide with the actual date that James Watson and Francis Crick discovered the double helix structure of deoxyribonucleic acid (February 28th 1953) in Cambridge, England. Each year, a theme related to DNA science is explored through a series of review-style talks aimed at a broad scientific audience. The theme of how cells repair damaged DNA and how mutations arise has been selected as the theme of the 2016 celebrations. The program will commence in the early afternoon (2.00pm) and conclude with an early evening reception (6.00pm) on Monday February 29th, 2016, and will be held in the Grace Auditorium at Cold Spring Harbor Laboratory.