The synthesis of heterocyclic compounds continues to attract enthusiastic endeavors designed to push the boundaries of what some have considered a mature field. Arguably, the boundaries of heterocyclic chemistry are limited only by ones' imagination. Heterocyclic compounds constitute the largest and most varied family of organic compounds with utility spanning photography to pharmaceuticals and beyond. New synthetic methods for heterocycle synthesis surface each month and are a testament to the rapid growth in this field. In fact, we are witness to the burgeoning growth of a field that has transformed society through spectacular innovations, implemented through applications of heterocycles in arenas spanning material science to new therapeutics for the treatment of cancer. The 2016 Heterocyclic Compounds GRC offers a contemporary look into state-of-the-art synthetic methods and a portico view of future directions and trends. At this conference, an extraordinary schedule of domestic and international speakers and an impressive lineup of posters will highlight recent advances in this field. Highlighted topics include heterocycles as redox mediators in organic electrochemistry, transition metal catalysis, natural product synthesis and heterocycles as the backbone of drug discovery. Please join us at this GRC for one of the most scientifically rich conferences of the year.