In the 1960s, Marshall McLuhan published the book entitled, The Extensions of Man focusing primarily on television, an electronic media as being the outward extension of human nervous system, which from contemporary interpretation marks the previous stage of Big Data. Based upon mathematical fundamentals as foundations for low-complexity algorithms, intelligent, flexible, and efficient, analytics architectures including both software and hardware for GPU, multicore, high performance computing, and distributed systems, the current panel innovates discussions on yet even further inward extension of human information perception experiences into genomic, proteomic, and other physiological and biomedical phenomena, in expediting the field of signal and information processing systems into futuristic new era of the Internet-of-Things and Cloud based on Algorithm/Architecture Co-Exploration.