The Asian pacific region is experiencing an unpreceded moment of economic expansion and urbanization. Engineers are expected to assure reliability and safety of infrastructures in an uncertain environment of increasing scale and increasing complexity. The proper design, construction, and maintance of the infrastractures is the key of the sustainable development of the region. Yet, either due to the inherent variability of the nature of due to our limitation in knowledge, the uncertainties in analysis, design, construction, and maintenance of infrastructures cannot be fully eliminated, posing substantial challenge to the reliability and safety of structures. In the past decades, great efforts have been exerted by both researchers and practitioners on how to design, construct, and maintain reliable structures. Relevant theories, methodologies, and tools have been developed to solve a large number problems. Nevertheless, assuring the reliability and safety of the infrasturactures in a realistic environment with increasing needs still seems to be challenging in many occasions. It is thus important to summreized what the profession has achieved, what is missing, and to identify what are to be further purse in the following two decades. This symposium aims to to provide an international forum for engineers, educators, researchers and practitioners to create a better understanding and vision about the current status and future of structural reliability and risk. The Asian-Pacific Symposium on Structural Reliability and its Applications (APSSRA) is held every four years in between ICASP and ICOSSAR. The first APSSRA was held in Tokyo, Japan in November 1995; the second in Taipei, Taiwan in February 1999; the third in Seoul, Korea in August 2004; the fourth in Hong Kong in June 2008, the fifth APSSRA in Singapore in May 2012, and the sixth will be held in 2016 in Shanghai, China with the following theme: Future structural safety and reliability: theories, methods, and tools.