You are cordially invited to participate in and attend the 2015 International Conference on High Performance Computing & Simulation to be held in Amsterdam, the Netherlands, July 20 – 24, 2015). The conference is to address, explore and exchange information on the state-of-the-art in high performance and large scale computing systems, their use in modeling and simulation, their design, performance and use, and their impact. Participation is extended to researchers, designers, educators and interested parties in all related disciplines and specialties.