The 28th annual meeting on The Biology of Genomes will begin at 7:30 pm on Tuesday, May 5, 2015 and run through lunch on Saturday, May 9. The 2015 meeting will address DNA sequence variation and its role in molecular evolution, population genetics and complex diseases, comparative genomics, large-scale studies of gene and protein expression, and genomic approaches to ecological systems. Both technologies and applications will be emphasized. In addition there will be a special session on the ethical, legal and social implications of genome research.