The Gordon Research Seminar on Directed Cell Migration is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. Directed cell migration is fundamental to cell positioning during morphogenesis, wound repair, immune trafficking and cancer metastasis. This GRS meeting will provide background and facilitate discussion on how models and predominant paradigms have both shaped and limited our understanding of directed cell migration.