You are cordially invited to participate in a new Cold Spring Harbor Laboratory meeting on Single Biomolecules. The opening session will begin at 7:30 pm on Tuesday, August 28 and the meeting will end after lunch on Saturday, September 1, 2018. As currently planned, the program will have eight sessions devoted to oral presentations, together with two poster sessions for presentations which cannot be accommodated in the formal sessions. Selection of talks for the oral sessions will be made by the organizers in conjunction with the session chairpersons, from the submitted abstracts.