The Bioorganic Chemistry Gordon Research Conference (GRC) was established in 1992 to bring together scientists pursuing challenges at the interface of chemistry and biology. Attendees from industry and academia meet annually to discuss the latest chemical tools that have been developed to modulate and interrogate biological complexity. The 2017 meeting will focus on liganding undruggable targets, targeting RNA with small molecules, chemical microbiology, the development of new chemical tools to unlock biology and translating small molecule probes into therapeutics. Conferees are encouraged to present posters. Poster presenters should submit an abstract with their applications on the GRC web site. A number of poster presenters will be invited to present short talks. As this meeting usually oversubscribes, submission of applications in early 2018 is strongly encouraged.