The Gordon Research Conference (GRC) on Cellular and Molecular Mechanisms of Toxicity is the premier forum for showcasing the latest, most innovative advances in mechanistic toxicological research. For the 2017 conference, the organizers have assembled a group of world-leading experts working on areas of investigation that are highly relevant to environmental, industrial, and pharmaceutical toxicology, with the goal of incorporating the molecular basis of disease into risk management and decision making. Emerging technologies in mechanistic toxicology and model and systems biology approaches to assessing risk to human disease will be highlighted along with the microbiome, epigenomics including noncoding RNA, application of new technology such as CRISPR/Cas9, and transgenerational mechanisms of toxicology. For the third consecutive time, a Gordon Research Seminar (GRS) on Cellular and Molecular Mechanisms of Toxicity will precede the conference. The GRS is organized and run by graduate students and fellows entirely and provides an expanded opportunity for trainees and young scientists to be exposed to cutting-edge science and to network with their future colleagues in the field. The poster session of the GRC is an essential element to the success of conference. Trainees and scientists at any level will have the opportunity to present their latest, groundbreaking work in poster format under an informal atmosphere that fosters relaxed dialog, networking and idea sharing. A special selection committee will select some abstracts/posters for short oral talks. These "late-breaking" oral sessions provide increased participation to trainees and young scientists to share their work with an audience of experts. This is a tremendous opportunity for the young talent to receive feedback from well-established leaders in the field. Another key to the success of the GRC is the social interaction of participants at meal times and during social activities in afternoon breaks. These interactions have led to long-lasting scientific collaborations and the lining up of trainees with laboratories for further education. We look forward to seeing you at the Gordon Research Conference on Cellular and Molecular Mechanisms of Toxicology in 2017!