The first objective of the meeting is to discuss and critically evaluate new breakthroughs regarding the molecular mechanisms that control excitation-contraction coupling (ECC), how this process is altered in genetically-inherited forms of skeletal and cardiac muscle disease, and in muscle fatigue, atrophy, sarcopenia, and how therapeutic intervention could reverse these alterations. The second objective is to promote visibility and leadership of junior investigators in the field by providing a platform for students, postdoctoral fellows, and new independent investigators to present their work, as well as to interact and network with established senior investigators. Scientific sessions will focus on structural studies of the ECC apparatus, new insights into the molecular mechanisms and regulation of ECC, identification of new therapeutic targets, and the development of innovative treatments for skeletal and cardiac muscle disorders with alteration in EEC. For the second time for this GRC, the meeting will be preceded by a two-day Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows. In addition, for each session during the GRC, a young investigator will be paired with a senior investigator to serve as Co-Discussion Leaders. Innovative "Poster Preview" and "Late-Breaking Topic" speaker slots will be used to highlight late-breaking news. These innovative program elements will also maximize poster session visibility, as well as enhance the integration and exposure of promising young investigators in the field during the GRC. The overall aim is to promote: 1) open dialogue and communication, 2) exposure and career advancement of promising young investigators in the field, 3) fundamental understanding in the mechanisms of ECC and how defects in this process lead to compromised skeletal and cardiac muscle performance, and 4) the development of novel and effective therapies to combat skeletal and cardiac muscle disorders affecting excitation-contraction coupling.