The 2017 Gordon Research Conference (GRC) on Alcohol-Induced End Organ Diseases "Metabolic Reprogramming and Molecular Mechanisms of Tissue Injury by Alcohol" will provide a unique forum to bring together a diverse range of young and established scientists who are studying alcohol-related organ damage. This newly approved Gordon Research Conference exclusively addresses alcohol-induced end organ disorders and will cover a broad range of studies at the molecular, cellular, systems, and organismal level, with particular emphasis on multidisciplinary work and innovative approaches. This GRC conference will 1) provide an international forum that promotes open discussion of cutting edge research at the forefront of alcohol-induced tissue injury, 2) foster the development of the next generation of investigators to study alcohol-induced organ damage, 3) promote interaction between young and senior investigators, 4) facilitate the exchange of ideas that will shape the future directions of the alcohol and tissue injury community, and 5) introduce breakthrough techniques that facilitate the understanding of mechanisms driving alcohol-induced tissue injury. This GRC conference will significantly advance current understanding of the underlying mechanisms of end organ injury and stimulate development of effective therapeutic strategies for the diagnosis, prevention and treatment of alcohol-related disorder. Talks will address questions centered on the basic mechanisms that contribute to alcohol-induced organ damage across the entire lifespan and will include wide ranging experimental systems from microbiome to humans. The format will provide ample time for formal and informal discussions and emphasize the presentation of unpublished data, thus ensuring that the newest and most exciting developments in the field are discussed. Poster sessions will take place on each day of the meeting, allowing for widespread participation of conference attendees at all career stages. Speakers will also be selected from submitted abstracts for "late-breaking topic" talks by young investigators. Participation by young investigators will be strongly encouraged.