The International Symposium on Integrated Circuits (ISIC) dates back to 1985 and is now recognized as one of the major conferences in the highly important field of theory, design, and implementation of integrated circuits and systems. The ISIC-2016, organized by Nanyang Technological University and IEEE Singapore Section, will be held in Singapore from 12 to 14 December 2016 with the theme “IC Design for Internet of Everything (IoE) towards a Smart City” to address the challenges and emerging issues of integrated circuit design and system integration. ISIC-2016 will offer a rich scientific program of the highest quality with distinguished invited speakers from all over the world and provide a broad forum of exchanges for researchers and IC designers.