Cloud Computing, as well as Cloud-inspired business models, enable on-demand access to a shared pool of resources, namely computing, storage, networks, services, and applications. With the advent of Cloud-based systems, cloud operators have been aiming at reliable, secured, privacy-preserving and cost-efficient cloud design and management. As the Cloud infrastructure aims at offering various IT resources as services, requirements of Cloud applications vary based on the resources which are requested as services. Thus, the resources may refer to heavy computation resources, massive storage resources, high-capacity network resources and so on. The heterogeneity of cloud applications leads to the challenge of holistic design of a robust Cloud system which can oversee and handle the diverse needs of numerous types of applications. On the other hand, these challenges enforce cooperation of various players in the Cloud system, each of which focuses on a different segment such as network, computing, applications, and systems. The International workshop on Cloud Computing Systems, Networks, and Applications (CCSNA-2016) aims at the crossroads between scientists, researchers, practitioners and students from diverse domains in Cloud computing research.