Probability and statistics have been widely used in almost all scientific fields including biology and public health. This workshop will concentrate on recent developments in probability theory, statistics, and their applications to biology. The applications to biology will range from next-generation sequencing, gene expression, molecular regulatory and interaction networks, pathways, statistical genetics, metagenomics, to system biology and clinical trials. The workshop will feature three internationally known keynote speakers: Michael Waterman (University of Southern California), Terry Speed (University of California at Berkeley), Minping Qian (Peking University), and other invited speakers from US, UK and China. A book related to this workshop will be published by Springer and entitled "Frontiers in Computational and System Biology." All speakers are invited to contribute a chapter to the book.