Cyber-Physical Systems (CPS) is recognized as an important trend of information technology and will deeply affect every day’s life of people. Theoretical and engineering aspects of CPS, such as its foundations, methods and tools, implementation techniques, attract a lot of research interests recently. The capabilities of CPS are realized by deeply embedded computation, communication and control, and their extensive interactions. As CPS is widely adopted in various critical areas (for example, distributed energy systems, transportation systems, and healthcare monitoring), its safety and security become key issues for its development and utilization. The safety and security problems faced by CPS have essential differences compared with traditional computing systems. The SSCPS workshop provides a forum to bring together researchers and practitioners working towards improving the safety and security of CPS and their related areas. The workshop focuses on innovative methodologies, techniques, tools, management and applications in this challenging area, and provides a chance of exchanging ideas on them.