Dear Colleagues: On behalf of the organizing and scientific committees, we invite you to participate in the National Medicinal Chemistry Symposium, to be held at the Palmer House Hotel in Chicago, Illinois, USA. The meeting will be held from Sunday, June 26 to Wednesday, June 29, 2016. The Palmer House Hotel is in the heart of the Loop, a block away from the Art Institute of Chicago and Millenium Park. NMCS 2016 is the 35th in the series initiated in 1948, and the meeting continues to be a centerpiece conference sponsored by the ACS Division of Medicinal Chemistry. We look forward to welcoming you to Chicago, and to an outstanding conference.