The 15th International Meeting on DNA Computing and Molecular Programming will be held June 8-12, 2009 in Fayetteville, Arkansas at the University of Arkansas. The conference will be hosted by The Department of Computer Science and Computer Engineering and The Department of Biological Engineering at The University of Arkansas, Fayetteville, AR. The organizing committee coChairs are Russell Deaton, CSCE and Jin-Woo Kim, Biological Engineering. Under the auspices of the International Society for Nanoscale Science, Computation and Engineering (ISNSCE), the conference expects to continue it strong tradition of presenting important research results and fostering interdisciplinary research. This annual conference focuses on topics that merge mathematics, computation, biology, and nanotechnology. Some examples are modeling of bionanoscale systems, using DNA oligonucleotides to guide the assembly of nanostructures, and implementing DNA-based computational devices for medical and other applications. The conference attracts top researchers in Computer Science, Mathematics, Chemistry, Physics, Molecular Biology, and Nanotechnology to foster interdisciplinary research in the molecular-scale manipulation of matter.