Research and application on cloud computing and intelligent systems have been extensively developed in recent years. We have witnessed numerous successes in various critical sectors of our society. As always, CCIS provides a forum for researchers and practitioners to exchange ideas and present their latest outputs, discuss challenging issues, and share experiences mainly in the field of cloud computing and intelligence systems. The past CCIS conferences were held in Beijing (2011), Hangzhou (2012), and Shenzhen & Hong Kong (2014), respectively. CCIS 2016, the 4th event of this exciting conference series, will be held at Beijing, August 17-19, 2016. The theme of CCIS 2016 is embracing challenges of cloud computing and intelligent technology at the age of big data. The conference will feature a comprehensive technical program, including a number of world class keynote speeches, frontline panel discussions, and session presentations. It is a great opportunity for learning, education, and information exchanging for all participants. The conference proceedings will be published by IEEE Press (EI indexed). Selected high quality papers from CCIS 2016 will be invited to a number of prestigious Special Issues after a solid extension. The tentative Special Issues are with IEEE Transactions on Systems, Man, and Cybernetics: Systems, Journal of Network and Computer Applications, Nurocomputing, and China Communications.