We are pleased to announce the eighth Cold Spring Harbor meeting on Gene Expression & Signaling in the Immune System, which will begin on Tuesday evening, April 26 and end at noon on Saturday, April 30, 2016. We are looking forward to a broad-based meeting, and abstracts are welcomed on all scientific topics related to immune system gene expression and signaling. In addition to a strong focus on lymphocyte development and adaptive immunity, this year's meeting will also emphasize the molecular regulation of innate immune responses.