Genomic sequencing is one of the most vital biological tasks today because of its promise to (1) improve human health through precision medicine, (2) discover sustainable sources of energy, and (3) help us better understand our world. This workshop is dedicated to discovering how to leverage HPC know-how to improve important biological processing that is critically dependent on a scalable compute and data infrastructure. We will also discuss some of the “human factors” that are necessary to glue the distinct computational, research and data components together. The ability to collaborate productively across disciplines is clearly an important component of advancing scientific throughput. We aim to help support the acceleration of scientific progress and innovation by spurring interdisciplinary understanding through human interaction.