The 22nd International Conference on Room-Temperature Semiconductor Detectors (RTSD) represents the largest forum of scientists and engineers developing new solid-state radiation detectors and imaging arrays. Room-temperature semiconductor radiation detectors are finding increasing applications in such diverse fields as medicine, homeland security, astrophysics and environmental remediation. The objective of this workshop is to provide a forum for discussion of the state-of-the-art of the detector technology, materials development, device and material characterization, electronics and applications. To provide a comprehensive review, oral and poster presentations representing a broad spectrum of research activities emphasizing either devices or materials understanding are sought.