The First International Workshop on Biological, Chemical and Physical Computations (BCPC’15) is a unique interdisciplinary workshop which brings together computer scientists and engineers with biologists, chemists, and physicists to initiate development of novel paradigms, architectures and implementations of computing devices adopting principles of information processing in physical, chemical and biological systems. The workshop aims to bring together world-leading scientists whose research focuses on non-traditional theoretical machines, experimental prototypes and genuine implementations of non-classical computing devices, who try to revisit existing approaches in unconventional computing, provide scientists and engineers with blueprints of realizable computing devices, and take a critical glance at the design of novel and emergent computing systems to point out failures and shortcomings of both theoretical and experimental approaches.