The 25th MLSP workshop in the series of workshops organized by the IEEE Signal Processing Society MLSP Technical Committee will take place in Boston USA and present the most recent and exciting advances in machine learning for signal processing through keynote talks, tutorials, as well as special and regular single-track sessions. The presented papers will be published in and indexed by IEEE Xplore and selected papers will be invited to submit extended versions to a special issue of the Springer Journal of Signal Processing Systems (JSPS).