The ICMSAO conferences started in 2005 at the American University of Sharjah (AUS), United Arab Emirates (UAE) as an effort to bring together engineers and scientists from around the world to share research results and to discuss future activities related to the areas of modeling, simulation, and optimization. The great success of the first conference with about 300 papers continued at the Petroleum Institute in Abu Dhabi, UAE, at AUS, UAE, in Kuala Lumpur, Malaysia, in Hammamat, Tunis. Istanbul has been the capital of the Roman Empire, the Byzantine Empire, and the Ottoman Empire. The 2010 European Capital of Culture offers exciting historical and natural attractions to all.