Over the past 12 years, the IEEE International ISI Conference has evolved from its traditional orientation of intelligence and security domain towards a more integrated alignment of multiple domains, including technology, humans, organization, and security. The scientific community has increasingly recognized the need to address intelligence and security threats by understanding the interrelationships between these different components, and by integrating recent advances from different domains. The breadth and rising ubiquity of the proposed theme will contribute to attracting high-quality submissions to ISI 2015, as well as reaching out to related international research communities, industry practitioners and technology providers, and government agencies and policy makers in the area of intelligence and security.