The International Conference on Systems Biology (ICSB) is the annual series of conferences initiated by Hiroaki Kitano and the ISSB in Tokyo in 2000. The meetings are catalysts for international collaboration in systems biology and have recently been held in Melbourne (2014), Copenhagen (2013), Toronto (2012) and Heidelberg/Mannheim (2011). Hosted by International Society of Systems Biology (ISSB) and Fudan University, the 16th International Conference on Systems Biology (ICSB) is taking place on August 20-26, 2015 in Shanghai, China. We are anticipating for more than 1,000 delegates and 30 exhibitors from different countries, and will consist of approximately 100 speakers across 4 days, a 1-day pre-conference workshop and a 2-day post-conference workshop. ICSB 2015 will become a unique platform for systems biology related scientist to share their theories, and more importantly, to form alliances of further researches and applications.