This conference series aim is to address the fundamentals of nano-mechanical interfaces using theory, computations and experiments. Nano-mechanical interfaces refer to systems where a nano-mechanical component interfaces with other physical components and materials. Nano-mechanical components include soft (fluids, polymers, cells, biomolecules, etc.) and hard materials (e.g. 1-D, 2-D and 3-D solids). The successful development of frontier technologies relies on exploitation and a comprehensive understanding of interfaces involving disparate materials and systems. Some examples include solid-solid, fluid-fluid, and solid-fluid interfaces, organic-inorganic interfaces, biotic-abiotic interfaces, multifunctional material interfaces, etc. Understanding the physical, mechanical, chemical, electrical, thermal and other important phenomena at interfaces and engineering better interfaces can lead to novel technologies in sensing, actuation, energy storage and conversion, confined catalysis, molecular separations, health monitoring and personalized medicine, etc. This conference focuses on experimental, theoretical and computational advances in nano-mechanical interfaces. Specifically, novel experimentation to probe interfaces, surfaces, confined physics, chemistry, and biology and novel nano-mechanical devices and systems are of interest. Multiscale theory and computational approaches ranging from quantum to atomistic to mesoscale and continuum approaches for nano-mechanical interfaces will be covered. Given the interdisciplinary nature of nano-mechanical interfaces, scientists and engineers from diverse backgrounds and disciplines will participate in this conference series.