The biannual Chromosome Dynamics Gordon Conference covers a broad range of topics at the forefront of current research into chromosome biology. Topics range from higher order chromosome organization and mechanisms of chromosome replication and segregation to the biophysical properties of single DNA and protein molecules. This GRC evolved from a meeting that focused on bacterial plasmid replication and segregation - the Bacterial Plasmid GRC - and has greatly expanded its scope to encompass new topics in all domains of life, bacterial, archaeal and eukaryotic. Unlike many excellent specialty meetings where experts in DNA metabolism, cell cycle progression, or gene expression delve into the intricacies of their fields, the Chromosome Dynamics GRC takes a different approach. It brings together participants with very different backgrounds and methodologies who, while presenting cutting-edge work in their respective fields, recognize the interrelatedness of seemingly distant approaches to the common goal of understanding the mechanisms that shape genomes. Lively crosstalk between researchers from these diverse disciplines makes this a favorite conference for many participants. In recognition of the global provenance of chromosome dynamics research, the Chromosome Dynamics GRC is held alternatingly in New England and in the hills of Tuscany at Il Ciocco, Italy.