We are pleased to host the tenth Cold Spring Harbor meeting on Eukaryotic mRNA Processing, which will begin at 7:30 pm on Tuesday, August 18 and run through lunch on Saturday, August 22, 2015. The meeting will focus on the mechanisms and regulation of mRNA splicing, polyadenylation, turnover, localization and RNA interference. It will include all aspects mRNA transport, processing and control, including ncRNA function, regulation of viral RNAs and disease implication of mRNA processing. The meeting is intended to provide a format for the exchange of ideas and information, to discuss the latest research findings and technical advances, and to facilitate interaction amongst groups active in diverse systems.