The next Cold Spring Harbor Laboratory conference on Genome Informatics will be held at Cold Spring Harbor, New York (this meeting has alternated with Hinxton meeting started under the joint auspices of CSHL and the Wellcome Trust). The meeting will begin on at 7.30 pm on Wednesday, October 28, and finish with lunch on Saturday, October 31, 2015 The focus for this conference is large-scale genome informatics. Biology is an experimental science that is experiencing an explosion of new data. This requires biologists to increase the scale and sophistication in the information technology used for their research. The conference scope encompasses the management and the analysis of these data, such as whole genome comparisons within and among species and strains, the analysis of results from high throughput experiments to uncover cellular pathways and molecular interactions, and the design of effective algorithms to identify regulatory sequence motifs. The conference brings together the leading scientists in this growing field, and we strongly encourage researchers from other large scale information handling disciplines to attend. The majority of oral presentations will be drawn from openly submitted abstracts.