We are pleased to host the 80th Cold Spring Harbor Symposium which will address 21st Century Genetics: Genes at Work in celebration of the 150th anniversary of Gregor Mendel’s landmark 1865 presentation of his paper “Experiments on Plant Hybridization”, which laid the groundwork for modern genetics. The Symposium will provide a current synthesis of genetic mechanisms and genome & chromosome biology and include more than sixty outstanding speakers in 12 oral sessions. We are accepting abstracts for consideration as poster presentations to be presented in 2-3 poster sessions throughout the meeting. Abstracts should contain only new and unpublished material and must be submitted by the abstract deadline.