You are cordially invited to participate in the third meeting on Biology of Cancer: Microenvironment, Metastasis & Therapeutics to be held at Cold Spring Harbor Laboratory, New York. The meeting will begin on Tuesday, May 12, 2015, and will conclude with lunch on Saturday, May 16. The specific goal of this conference is to nucleate scientists who are investigating these diverse aspects of cancer biology and facilitate discussions aimed at finding ways to combine these fields to develop novel therapeutic strategies to control cancer. The meeting will alternate annually with the CSHL meeting on Mechanisms & Models of Cancer. The format of the meeting will include morning and evening sessions consisting of eight or nine 15-minute talks per session, selected from the abstracts, principally on unpublished work. In addition, there will be two poster sessions, held in the afternoons. The organizers will decide the suitability of each abstract for oral or poster presentation, but please specify if you prefer a poster.