We are pleased to announce a new Cold Spring Harbor meeting on Fundamental Immunology & Its Therapeutic Potential, which will begin on Tuesday evening, April 14 and end at noon on Saturday, April 18, 2015. The meeting will have a unique focus aimed at enhancing fundamental immunology research while speeding the translation of basic immunology discoveries to the clinic. The immunology field has entered an exciting new era in which our expanding knowledge of immune regulation is leading to innovative new therapies for the treatment of cancer, infectious diseases, autoimmune and inflammatory disorders, and other diseases. Future clinical advances will continue to be driven by fundamental discoveries, highlighting the importance of strong interactions between basic and translational researchers. Furthermore, it has been firmly established that research advances originally made while studying one type of disease can lead to important therapeutic advances in another disease. One striking example is the remarkable success of checkpoint blockage therapies for the treatment of cancer, drawing on initial fundamental studies in infectious disease models. With these issues in mind, the objective of this new meeting will be to bring leading senior and junior investigators working on fundamental questions in immunology together with an equally strong group of researchers who have had experience and success translating fundamental advances to the clinic. The meeting will also promote interactions between researchers working on diverse diseases, by including cancer, infectious diseases, autoimmunity and other relevant diseases.