The 2015 Gordon Research Conference on Cardiac Arrhythmia Mechanisms will provide a forum in which cutting edge concepts and new observations on mechanisms and treatment of complex cardiac rhythm disturbances are discussed, at levels of integration ranging from molecule to the patient. The meeting will focus on key scientific discoveries, relevant to both basic science and the clinic, emphasizing multi-disciplinary approaches to integrating the latest (and, to a large extent, unpublished) advances in structural biology, genomics, proteomics, stem cell research, cellular and tissue electrophysiology, high-resolution electro-mechanical mapping, and computational modeling to study of the hetero-cellular nature of cardiac arrhythmogenesis and anti-arrhythmic therapy. This represents an exceptional opportunity for bringing together an internationally leading selection of outstanding investigators who are experts in various relevant fields, including biologists, geneticists, electrophysiologists, biophysicists, biomedical engineers, mathematical biologists, computer scientists, and clinical cardiologists to interact in an informal atmosphere and share ideas about the ‘multi-physics’ nature of mechanisms underlying normal and disturbed heart rhythms, including causes of sudden cardiac death. Even more so that in previous years will we have an explicit focus on peer interactions with, and mentoring of, trainees and junior investigators, who (for the first time in the Cardiac Arrhythmia Mechanisms GRC history) will have 'their own' 2-day Gordon Research Seminar prior to the GRC.