Bioimaging has continued to evolve across a wide spectrum of applications from diagnostics to personalized therapy to mechanistic understanding of biological processes. The field continues to be challenged with ever increasing demand on more robust methods and integration with clinical and molecular data. The 2015 IEEE International Symposium on Biomedical Imaging will be held April 16-19, at the New York Marriott at Brooklyn Bridge, NY, USA. ISBI is a joint initiative of the IEEE Signal Processing Society (SPS) and IEEE Engineering in Medicine and Biology Society (EMBS).