The purpose of the 5th International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH) is to bring together researchers, engineers, applied mathematicians and practitioners interested in the advances and applications in the field of system simulation. Four simultaneous tracks will be held, covering on one side domain independent methodologies and technologies and on the other side practical work developed in specific application areas. The specific topics listed under each of these tracks highlight the interest of this conference in aspects related to computing, including Conceptual Modeling, Agent Based Modeling and Simulation, Interoperability, Ontologies, Knowledge Based Decision Support, Petri Nets, Business Process Modeling and Simulation, amongst others. SIMULTECH focuses on bridging formal methods and real world applications; therefore authors should highlight the benefits of Simulation Methodologies and Technologies for industry and services, either in general or for particular applications. Ideas on how to solve business problems, using simulation and modeling methodologies and technologies, will arise from the conference. Papers describing advanced prototypes, systems, tools and techniques and general survey papers indicating future directions are also encouraged. Papers describing original work are invited in any of the areas listed below. Accepted papers, presented at the conference by one of the authors, will be published in the Proceedings of SIMULTECH. Acceptance will be based on quality, relevance and originality. Both full research reports and work-in-progress reports are welcome. There will be both oral and poster sessions. Special sessions, dedicated to case-studies and commercial presentations, as well as tutorials dedicated to technical/scientific topics are also envisaged: companies interested in presenting their products/methodologies or researchers interested in holding a tutorial, workshop or special session are invited to contact the conference secretariat or visit the conference website.