The 49th Annual Conference on Information Systems and Sciences will be hosted by Johns Hopkins University Whiting School of Engineering’s Department of Electrical and Computer Engineering from Wednesday through Friday, March 18 to 20, 2015. Authors will present unpublished papers describing theoretical advances, applications, and ideas in the fields of Information Sciences and Systems, including signal and image processing and analysis; communications and information theory; systems biology and biological control; computer engineering; systems and control theory; and photonic systems.