Fourth in the biennial series, the EORTC-EANO-ESMO 2015 Conference is supported by the Turkish Neuro-Oncology Society and will be held in the charming city of Istanbul on 27-28 March 2015. The main focus of the 'Trends in Central Nervous System Malignancies' Conference is to improve the neuro-oncology field, accelerate the translation of cutting edge discovery at the clinical level, and further promote international scientific co-operation, debate and exchange. Adopting a highly multidisciplinary approach, the EORTC-EANO-ESMO 2015 Conference will aim to draw an attendance of neuro-oncologists, neuro-radiologists, neuro-surgeons, neurologists, neuro-pathologists, medical oncologists, and radiation oncologists sharing the common goal of advancing the management, treatment and care of patients with central nervous system tumours, including gliomas, brain and spine metastatic disease, meningioma, CNS lymphoma and primary spinal cord tumours.