The vision of Cyber Physical Systems goes far beyond the traditional world of real-time embedded systems by integrating a number of characteristics such as autonomy, distribution, large-scale, real-time, dynamic behavior, etc., that pose enormous challenges to their design and development. More complex hardware and software architectures are required by the current and future generation applications where computing is distributed across a network of interconnected and possibly heterogeneous processing units where the functional software and hardware pieces are not necessarily static. Soft real-time co-exists with hard real-time, and high level software infrastructures and communication middleware play an increasingly important role in the overall picture. At the same time, the world of high-end parallel and distributed computing systems and applications, in its continuously evolving declinations in the form of High-Performance Computing, GRID Computing, Service- Oriented and recently Cloud Computing, is generally paying more and more attention to issues related to Quality of Service, predictability of the timing behavior, interactivity, and real-time performance. Providing real-time guarantees in the cyber-physical distributed computing arena raises a number of challenging scientific and engineering problems that span across a variety of research areas, such as: real-time computing, parallel and distributed systems, software engineering and architectures, dependability, and virtualization. From different though related research communities, researchers are heading towards the same point possibly walking parallel paths with the goal of effectively and efficiently providing the level of temporal guarantees required by the new complex systems, spanning from temporal predictability to QoS guarantees. Solutions from different communities present interesting approaches that can benefit from meeting at a common forum with the goal of drawing a complete picture of the problem and of the possibility of identifying novel research areas as resulting from this crossbreading. From its original conception, REACTION workshop aims at providing a forum for presentation and discussion of the contributions and ideas of researchers working on real-time systems and distributed systems for the next-generation applications. The goal is to bring together contributions on both practical and theoretical aspects applied to the integration of real-time support in these new computation paradigms.