Understanding networks and networked behavior has emerged as one of the foremost intellectual challenges of the 21st century. It is fair to say that in the last fifty years we have been able to engineer networks that have transformed our world. Yet, while we obviously master the technology to do so, our theoretical understanding of fundamental phenomena that arise in networked systems remains limited. The purpose of this symposium is to bring together researchers from Signal Processing, Information Theory, and Controls to share their recent ideas and progress in the development of a fundamental understanding of networks and networked behavior.