The 22nd Biennial Winter Fluorine Conference, sponsored by the ACS Division of Fluorine Chemistry, will be held at the TradeWinds Island Grand Resort, in St. Pete Beach, FL, on January 11–16, 2015. The conference will feature invited plenary and oral presentations as well as contributed papers and posters by fluorine chemists. This conference provides a forum to discuss progress in modern Fluorine Chemistry including new developments in Organic, Inorganic, Physical, and Medicinal and Biological Chemistry.